Friday, September 20, 2013

Journal Club: Nucleosome prediction

This week's journal club paper was: Genome-wide analysis of histone H3.1 and H3.3 variants in Arabidopsis thaliana Stroud et al. (2012)

The number of existing datasets that Stroud et al. were able to pull genomic data from was, I think, a nice example of putting Arabidopsis' rich research history to good use. It's also nice to see when some general chromatin features are conserved between plants and animals, although its quite surprising/borderline unbelievable that H3.1 and H3.3's functions in both systems are a product of convergent evolution.

My comment:

"It's not really the purpose of the paper, but I was excited to see that there exists a nucleosome prediction algorithm that appears to work well in C. elegans and, as this paper suggests, in Arabidopsis.  I think the idea that DNA sequence is a good predictor of nucleosomal location across large evolutionary distances could permit searching for higher order chromatin structures on the basis of DNA sequence."

No comments:

Post a Comment